Day 1 :
- Obesity Genetics
Session Introduction
Priti Nanda Sibal
Mediskool Health Services, India
Title: Diabetes: 7 Things You Forget to Do
Biography:
Dr priti has completed her fellowship in Anti-aging & Regenerative Medicine from American Academy of Anti-aging & regenerative medicine, USA. She holds an MBBS from GNDU, Amritsar, India and a PGDM degree from IIM Lucknow, India. She has published few papers on Diabetes Reversal and has authored 2 books – Cyclic Keto & 4-Hour Rapid Fat Loss Method.
Abstract:
Most diabetes patients find themselves on the road to gradually increasing weight, uncontrolled blood glucose levels, higher doses of medications, poor quality-of-life, and worsening complications. Although lifestyle modifications are usually recognized to be the first-line treatment of Type-2 diabetes, adequate glycemic control is difficult to achieve. Though pharmacological agents help manage the symptoms of diabetes, they cannot prevent the progression of the disease or the complications arising from the disease.
Functional medicine aims at reversing the trend of weight increase, uncontrolled blood glucose levels, and worsening complications, thereby reversing diabetes. Not only can this reduce higher medication doses required; it also enables a faster and sustained reduction of blood glucose concentration, alleviates symptoms of diabetes and complications associated with it, tackles weight gain, and even counteracts the severity of heart disease.
The case presented below illustrates the role of functional medicine in improving patient’s quality-of-life in stage 3 diabetes. The case establishes how the functional medicine approach can effectively reverse the pathology and progression of Type-2 diabetes in an obese patient. Our recommendations for him comprised dietary and lifestyle changes, exercise regimen, functional food, nutritional supplements, and stress management. The patient showed significant improvement at the end of 4 months of therapy, managing various aspects of diabetes, including healthy weight loss, redeemed energy, alleviation of pain, and a better quality of daily life.
Shilpa Varma
Bellevue Multispecialty Hospital, Mumbai, India
Title: A Study on Prevalence of Abdominal Obesity Among Adult Diabetes Mellitus Type 2 Patients
Biography:
Dr Shilpa Varma (PhD, MSc Dietetics and Applied Nutrition) is Chief Clinical Nutritionist Bellevue MultiSpeciality Hospital, T2T Hormone Clinics, India, Mumbai and Child Hormone Foundation, Mumbai. She is National Executive Committee Member IAPEN India Association for Parenteral and Enteral Nutrition. She is Chief Program Officer IAPEN Nutrition and Diabetes India. She is a Director Partner at HealthyHey Nutrition Company. She is a visiting faculty at D.Y. Patil University, Navi Mumbai. She is the member of various National and International Associations. She has co-authored many text books and FSSAI manual and various publications
Abstract:
Rapid globalization and industrialization principally in developing countries may contribute to substantial increase in lifestyle related diseases. Obesity has turned into one of the global health burdens of 21st century. Indian population is passing through transition phase where sustenance circumstances are being replaced by abundant availability of food but reduced physical work. There are considerable researches connecting obesity as major risk factor in development of diabetes. Nonetheless, it is now being recognized that for given BMI, central adiposity rather than lower body fat distribution poses considerable risk of metabolic and cardiovascular complications of obesity. The aim of this study was to evaluate quantitative evidence on relationship between abdominal obesity and the incidence of type 2 diabetes in adults, both genders, and to scrutinize the relative adequacy of different measures of abdominal obesity. A cross-sectional study was carried out from March 2020 to July 2020 in the out-patient department. The sample size was 198 patients and aggregate age of the study subjects was 56 years and 72.62% had Women: > 80 cm and Men: > 94 cm. Though waist circumference cannot discern abdominal subcutaneous fat, total abdominal fat and total body fat but is dynamically correlated with BMI and is easily measured and can be monitored by patients themselves. Exhibiting a strong co-relationship of increased abdominal obesity to incidence of type 2 diabetes this study proposes that simple measure of abdominal obesity in everyday practice may help identify patients at increased risk of developing type 2 diabetes.
Akanksha Singh
CSIR-NEERI, Nagpur, India
Title: Adipocyte Nanobodies may combat the inheritable obese traits in the foetus
Biography:
Dr Akanksha Singh is affiliated from CSIR-NEERI, Nagpur, India.
Abstract:
Adiponectin is an obese hormone that is collagenous in nature and exclusively synthesized in white adipose tissues. Although, it acts as an important mediator in glucose and lipid mediated metabolic pathways, it is largely involved in the disorders such as obesity[1] .Adipocyte gene (ADIPOQ) is mainly responsible for the formulation of adiponectin protein i.e.247 amino acids and 30KDa with amino and carboxy terminal domain and a collagenous domain. Adiponectin protein has a high affinity for receptors such as Adipo R1 and Adipo R2[2]. These two receptors are activated in response to interaction with another biomarker APPL 1. The functioning of Adipo R1 and R2 need to be supressed for the decreased sensitivity of the fat inducer adiponectin[3]. Nanobodies are synthesized that contains high concentration of APPL1 that will not allow the binding of Adipo receptors to the adiponectin protein[4][5]. The concentration of engineered nanobodies were then determined by ELISA technique[6]. These nanobodies were then injected in the fetal cells and after 24-48 hours, the concentration was determined. Low levels of adiponectin were observed due to failed interaction with the adipo receptors. This review focusses on the action of engineered nanobodies on the adiponectin protein and its effect on the obesity.
M Van Stad
University of Limpopo, South Africa
Title: No easy solution for a complex problem- Maintaining healty body weight and preventing overweight and obesity
Biography:
Professor Marlise van Staden has completed her PhD at the age of 32 years from the North West University. She is the Head of the Department of Physiology and Environmental Health at the University of Limpopo in South Africa. Her research area is chronic degenerative diseases (including obesity) and child health. (Up to 100 words).
Abstract:
In recent decades the prevalence of obesity has increased to reach epidemic proportions, this despite the fact that the condition is completely preventable and treatable. Worldwide obesity has nearly tripled between 1975 and 2017. The condition is no longer limited to adults or to populations in developed countries. In 2016 more than 340 million children and adolescents between the ages of five and nine years were overweight or obese, and in 2020, 39 million children younger than 5 years of age were overweight or obese. Furthermore, the majority of the global population live in countries where overweight and obesity kills more people than underweight. What is this condition? What causes it? Which complications are associated with the excess body weight? Most importantly why do so many people suffer and die from a preventable, treatable condition? One can simplify obesity to a positive enery balance due to a higher energy intake compared to the energy expenditure of the individual. The solution to this simplified problem seems simple – reduce energy intake and increase energy expenditure. However, the truth is that obesity is much more complex than a mere energy imbalance and for this reason the solution is not as simple as it seems. This presentation will aim to investigate the complexity of obesity as a health problem and briefly look at some ways to manage, prevent and treat obesity.